Harley Quinn has finally broken things off once and for all with the Joker. Now, she's trying to make it on her own as the criminal Queenpin of Gotham City, with help from Poison Ivy and a ragtag crew of DC castoffs.
This season finds Harley and Ivy in a new location: Metropolis! – the home of all things Superman, Lois Lane, and the Daily Planet. Harley and Ivy discover that something sinister is at play and all is not what it seems. Looming threats include Lex Luthor and his sister, Lena Luthor, plus fan-favorite Brainiac. But of course, Harley's crew of misfits and allies will join her on this irreverent journey that takes no prisoners in having fun in the DC sandbox.