Kobayashi lives alone in an apartment, until one day, Tohru appeared and they ended up living together. Tohru looks down on humans as inferior and foolish, but having been saved by Kobayashi-san, she does everything she can to repay the debt and help her with various things, although not everything goes according to plan. A mythical everyday life comedy about a hard working office lady living with a dragon girl.
A strange turn of events leads the Dragon, Tohru, to work as Miss Kobayashi's maid. She occasionally (that's a lie, she often) causes trouble for her beloved Miss Kobayashi while blending into human society and splendidly (that's a lie, only mediocrely) carrying out her maid duties. Her fellow dragons, Kanna, Lucoa, Fafnir, and Elma all find their own places to fit in as well and enjoy interspecies interactions with the humans. Yet while they're all enjoying that laid-back and occasionally turbulent left, the threat of a new Dragon swoops down upon Miss Kobayashi.