Dante, a demon hunter, runs an agency called “Devil May Cry”. He is hired to protect Patty Lowell, a little orphan girl who has just received her late father's entire estate. At the same time as Patty wants to find her mother, her relatives and the demons want to kill her in order to keep the inheritance that was meant for her. To top it off, the demons want the mysterious necklace that the helpless little girl is wearing. What could be so important about this jewel?